<internation circulation>:
Do you have any other advice for dealing with Cardio-renal syndrome?

Gottlieb：
There are a lot of ways of looking at Cardio-Renal syndrome.  I think the clinically important definition is that cardio-renal syndrome is a state where fluid overload can not be treated without worsening renal function; those patients need more aggressive treatment and an appropriate use of diuretics is important.